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Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter

delete2026-06-27
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H
Hong‐Hsi Lee *
A
Ali Abdollahzadeh
H
Hansol Lee
R
Ricardo Coronado-Leija
E
Els Fieremans
S
Susie Y. Huang
D
Dmitry S. Novikov
DOI:10.1002/mrm.70490delete
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Abstract

Abstract

En 中文
The dependence of the long-time (tortuosity) limit of the extra-cellular diffusivity on the intra-cellular volume fraction is of fundamental importance for microstructure modeling. While such dependencies have been explored for the white matter, the tortuosity limit in gray matter is unknown due to complex cell composition and geometry. Here we rationalize and validate numerically the analytical relation between the extra-cellular diffusivity and intra-cellular fractions of cell bodies (somas) and neurites.
Keywords:
diffusion MRI
effective medium theory
extra-cellular space
tortuosity
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Journal

Magnetic Resonance in Medicine cover
Magnetic Resonance in Medicine
IF:
3
Papers:
1.2W
Citations:
3.1W

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M
massachusetts general hospital
Scholars:
3.1K
Papers: 1.5K
Citations: 0
N
New York University School of Medicine
Scholars:
21
Papers: 13
Citations: 0
U
University of Eastern Finland
Scholars:
1.4W
Papers: 1.2W
Citations: 1.5W
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