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Depression vulnerability involves brain activity and connectivity changes consistent with cholinergic deviancy
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DOI：10.1016/j.nicl.2025.103941.png)
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Abstract
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• Depression vulnerability markers are shared by patients and their family members. • fMRI markers show changed dorsal attention activity during face perception. • Changes are consistent with acetylcholine-mediated moderation of top-down influences. • These changes are seen in family members with no own history of depression. • Vulnerability for depression involves general changes in neural processing of events.
Keywords:
Major depression disorder
Face perception
Task-related fMRI
Resting-state functional connectivity
Visual attention network
Acetylcholine
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