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Design and Utilization of Stable Hydrofluoroolefin-Based Trifluoropropynyl Surrogate for Sonogashira Coupling
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DOI：10.1002/adsc.70072.png)
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Abstract
En 中文
The synthesis of aromatic trifluoromethylated scaffolds is of considerable importance in organic chemistry and pharmaceutical research. Herein, a catalytic method with broad functional group tolerance for the construction of aromatic and heteroaromatic trifluoropropynyl derivatives is reported. This methodology is based on a tandem Sonogashira cross-coupling reaction between an hydrofluoroolefins-based carbinol and (hetero)aryl iodides. The developed protocol employs inexpensive and commercially available HFO-1234yf gas to generate a bench-stable trifluoropropynyl carbinol reagent.
Keywords:
carbinols
copper
cross-coupling
hydrofluoroolefins
palladium
trifluoromethylated arylacetylenes
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