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Designed protease-based signaling networks
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DOI：10.1016/j.cbpa.2022.102146.png)
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Abstract
En 中文
Regulated proteolysis is a pivotal regulatory mechanism in all living organisms from bacteria to mammalian cells and viruses. The ability to design proteases to sense, transmit, or trigger a signal opens up the possibility of construction of sophisticated proteolysis-regulated signaling networks. Cleavage of the polypeptide chain can either activate or inactivate the selected protein or process, often with a fast response. Most designs are based on sequence-selective proteases that can be implemented for transcriptional, translational, and ultimately post-translational control, aiming to engineer complex circuits that can dynamically control cellular functions and enable novel biotechnological and biomedical applications.
Keywords:
Proteolysis
Viral proteases
Endogenous proteases
Protease-based
sensors
Synthetic signaling cascades
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