arrow
Return

Designing physics experiments with artificial intelligence

delete2026-09-02
delete0
PRE
AI
J
Jonathan Klimesch *
S
Sören Arlt
C
Carlos Ruiz-Gonzalez
C
Carla Rodríguez
X
Xuemei Gu
P
Philipp Haslinger
P
P. Vischia
C
Christian Haack
Y
Yehonathan Drori
R
R. X. Adhikari
M
Markus Arndt
M
M. Kagan
L
L. Heinrich
M
Mario Krenn *
DOI:10.1038/s41586-026-10898-6delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Progress in physics has long been driven by ingenious experiments conceived by human experts. Recently, design methods driven by artificial intelligence (AI) have begun to move beyond tuning a handful of parameters to proposing entirely new experimental layouts. The discovered configurations often challenge established design conventions while matching or even exceeding the performance of human-designed set-ups. We frame experimental design as a search for optima over a vast space of hardware configurations subject to practical constraints and organize this Review around four guiding questions: how can we (1) engineer expressive search spaces; (2) build fast and reliable simulators; (3) translate scientific goals into computable objective functions; and (4) develop AI-based exploration methods that can navigate both discrete and continuous design choices. These questions place AI-driven design on a scale from parameter tuning to de novo discovery, and highlight the trade-offs between computational tractability, experimental feasibility, interpretability and solution reliability. Looking ahead, simulators spanning several physics domains, combined with large suites of experimental objectives, could discover unorthodox experimental concepts that are difficult to arrive at with human intuition alone. Ultimately, AI-designed experiments might thereby open new ways to explore the Universe. Artificial intelligence in physics experimental design is explored on the basis of searching for optima over a vast space of hardware configurations and proposing entirely new experimental layouts, rather than tuning a handful of parameters.

Journal

Nature cover
Nature
IF:
48.5
Papers:
1.8W
Citations:
96.5W

Organization

F
FAU Erlangen-Nurnberg
Scholars:
2
Papers: 2
Citations: 0
T
technical university of munich
Scholars:
7.0K
Papers: 2.8K
Citations: 1
T
tu wien
Scholars:
637
Papers: 224
Citations: 0
U
University of Tübingen
Scholars:
416
Papers: 158
Citations: 0
S
SLAC National Accelerator Laboratory
Scholars:
4.2K
Papers: 2.5K
Citations: 1.7W
M
max planck institute for the science of light
Scholars:
42
Papers: 11
Citations: 0
C
california institute of technology
Scholars:
2.7K
Papers: 1.1K
Citations: 0
U
university of vienna
Scholars:
2.7K
Papers: 1.4K
Citations: 0
T
tel aviv university
Scholars:
5.6K
Papers: 2.1K
Citations: 1
Universidad de Oviedo cover
Universidad de Oviedo
Scholars:
481
Papers: 190
Citations: 1.0W
researcher View more organizations