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Detection of a four-carbon sugar in interstellar space
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DOI：10.1038/s41550-026-02905-7.png)
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Abstract
En 中文
Sugars are essential biomolecules, serving as metabolic fuels, nucleic acid backbone components and structural or energy-storage polymers. A central question in origin-of-life research is how monosaccharides formed on the primitive Earth, as laboratory experiments under prebiotic conditions yield insufficient concentrations. The detection of ribose, glucose and other monosaccharides in asteroids and meteorites suggests an exogenous origin, possibly in the interstellar medium (ISM) before meteoritic parent-body formation. However, no sugar has been observed in the ISM so far. Here we report the discovery of erythrulose, a chiral four-carbon ketose, in the ISM. The detection was achieved through ultrasensitive, broadband spectral surveys of the Galactic Centre molecular cloud G+0.693−0.027, using the Yebes 40 m and IRAM 30 m telescopes. Erythrulose appears to be at least eight times more abundant than analogous three-carbon sugars, which remain undetected in our ultrasensitive observations. Quantum chemical and astrochemical models indicate that erythrulose forms efficiently on interstellar dust grains from simpler two-carbon aldehydes and alcohols. As ketoses readily isomerize into aldoses in aqueous conditions, interstellar erythrulose could have contributed to the sugar inventory available for early metabolic and replication processes. A monosaccharide sugar has been detected in an interstellar cloud: the chiral ketose erythrulose. Observations and chemical modelling show that it forms efficiently on dust grains, supporting an interstellar origin for prebiotic sugars linked to early life.
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