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Developing Conductive Materials for Peripheral Nerve Interfaces

delete2025-10-01
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PRE
AI
张
张辉 (Hui Zhang)
L
Ling Lü *
Y
Yu Wang *
赵
赵远锦 (Yuanjin Zhao) *
DOI:10.1002/smtd.202501219delete
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Abstract

Abstract

En 中文
Peripheral nerve interfaces serve as critical bridges between the nervous system and external devices, with wide-ranging applications in nerve repair and neuroelectronics. However, conventional interface materials often present mechanical and biological mismatches with native neural tissues, limiting their long-term performance and biocompatibility. In recent years, conductive materials have garnered increasing attention in the development of peripheral nerve interfaces due to their excellent electrical conductivity and multifunctional design potential. By enabling flexible architectures, enhancing interfacial compatibility, and incorporating biofunctional elements, these materials facilitate efficient signal transmission and precise neuromodulation. Here, recent advances in the application of conductive materials in peripheral nerve interfaces is systematically highlighted, with a focus on their roles in electrode coatings, implantable electrode substrates, and bioactive scaffolds for nerve regeneration. We further discuss the key challenges facing the field and provide perspectives on future directions toward clinical transition.
Keywords:
Conductive hydrogels
conductive materials
conductive polymers
nerve regeneration
peripheral nerve interfaces

Journal

Small Methods cover
Small Methods
IF:
9.1
Papers:
4.3K
Citations:
2.2W

Organization

N
Nanjing University
Scholars:
7.0K
Papers: 2.6K
Citations: 8.1W
S
southeast university - china
Scholars:
5.3W
Papers: 4.9W
Citations: 57
Cited Papers

Cited Papers

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errWon, Daeyeon; Kim, Jin; Choi, Joonhwa; Kim, HyeongJun; Han, Seonggeun; Ha, Inho; Bang, Junhyuk; Kim, Kyun Kyu; Lee, Youngseok; Kim, Taek-Soo; Park, Jae-Hak; Kim, C-Yoon; Ko, Seung Hwan
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A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve
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errBoretius, Tim; Badia, Jordi; Pascual-Font, Aran; Schuettler, Martin; Navarro, Xavier; Yoshida, Ken; Stieglitz, Thomas
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Ultrasound-Responsive Composited Conductive Silk Conduits for Peripheral Nerve Regeneration
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errZhang, Hui; Wang, Huan; Wen, Baojie; Lu, Ling; Zhao, Yuanjin; Chai, Renjie
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Highly-stable, injectable, conductive hydrogel for chronic neuromodulation
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errYang, Ming; Wang, Lufang; Liu, Wenliang; Li, Wenlong; Huang, Yewei; Jin, Qiaofeng; Zhang, Li; Jiang, Yuanwen; Luo, Zhiqiang
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An Easy Nanopatch Promotes Peripheral Nerve Repair through Wireless Ultrasound-Electrical Stimulation in a Band-Aid-Like Way
err2024-08-03
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PREAI
errLiu, Yang; Zhang, Zhifa; Zhao, Ziteng; Xu, Yongde; Duan, Xiaofeng; Zhao, Yantao; Ma, Wenjing; Yang, Yong; Yang, Yafeng; Liu, Zhiqiang
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Soft, stretchable conductive hydrogels for high-performance electronic implants
err2025-03-21
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errOAAI
errRahman, Md Saifur; Shon, Ahnsei; Joseph, Rose; Pavlov, Anton; Stefanov, Alex; Namkoong, Myeong; Guo, Heng; Bui, Dangnghi; Master, Reid; Lee, Jennifer; Rivas, Melissa; Elati, Ananya; Zhao, Feng; Park, Hangue; Hook, Michelle A.; Tian, Limei
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Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration
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errLiu, Kai; Yan, Shuai; Liu, Yao; Liu, Jianfeng; Li, Ruijun; Zhao, Lirong; Liu, Bin
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