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Development and characterization of phantoms to investigate the Flash effect with Drosophila melanogaster at an ultra-high dose rate radiotherapy linac

delete2025-09-15
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R
Riccardo Dal Bello *
M
Marvin Kreuzer
I
Irene Vetrugno
J
Jamie C Little
R
Rafael Kranzer
S
Stefan Schischke
L
Lily Bossin
E
E.G. Yukihara
M
Matthias Gückenberger
M
Martin Pruschy
S
Stephanie Tanadini‐Lang
DOI:10.1016/j.phro.2025.100835delete
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Abstract

Abstract

En 中文
• Developed phantoms for the irradiation of Drosophila melanogaster. • Converted a conventional linac to ultra-high dose-rate radiotherapy. • The setup allowed comparison of conventional and Flash dose rates. • Biological endpoints at up to 1000 Gy could be investigated. • Production of photon megavoltage UHDR was demonstrated at a clinical linac.
Keywords:
Drosophila melanogaster
Flash
Ultra-high dose rate
Linac
Electron
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Physics and Imaging in Radiation Oncology cover
Physics and Imaging in Radiation Oncology
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3.3
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850
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radpro international gmbh
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U
university of zurich
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P
ptw-freiburg
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University Hospital Zurich and University of Zurich
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95
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Paul Scherrer Institute
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