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Development and validation of a miRNA-based prognostic model for high-grade serous ovarian cancer: a retrospective cohort study

delete2026-06-05
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OA
AI
C
Cristiane Esteves Teixeira
N
Nayara Gusmão Tessarollo
G
Glenerson Baptista
A
Alessandra Freitas Serain
H
Helena Zancanaro
D
Diego J. Gomes de Paula
L
Luciana Castro Moreeuw
C
Cláudia Bessa Pereira Chaves
J
João P.B. Viola
A
Alexandre Dias Porto Chiavegatto Filho
M
Mariana Boroni *
DOI:10.1016/j.lana.2026.101527delete
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Abstract

Abstract

En 中文
Ovarian cancer, particularly high-grade serous ovarian cancer (HGSOC), is the most lethal gynecological malignancy, mainly due to late-stage diagnosis and limited prognostic biomarkers. Current clinical markers, such as CA125, have limited prognostic accuracy for risk stratification. MicroRNAs (miRNAs) have emerged as promising biomarkers due to roles in tumor biology and stability in biofluids. This study aimed to identify and validate prognostic miRNA biomarkers in HGSOC.
Keywords:
miRNA-based prognostic model
High-grade serous ovarian cancer
Machine learning in oncology
Prognostic biomarkers
Explainable AI
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Journal

T
The Lancet Regional Health - Americas
IF:
0
Papers:
174
Citations:
0

Organization

U
university of são paulo
Scholars:
1.7K
Papers: 547
Citations: 0
B
Brazilian National Cancer Institute
Scholars:
47
Papers: 19
Citations: 0