Development of a gene signature related to phospholipid metabolism for prognosis and therapeutic Prediction in Osteosarcoma: Focus on VAC14

Yihui Liang

doi:10.1016/j.gene.2026.150290

Development of a gene signature related to phospholipid metabolism for prognosis and therapeutic Prediction in Osteosarcoma: Focus on VAC14

2026-06-24

0

PRE

AI

Y

Yihui Liang

Y

Yiwen Ba

Q

Qiwei Zhou

J

Jiangwei Xuan

W

Wenfei Ni *

C

Chenyu Wu *

J

Jingdi Zhan *

DOI：10.1016/j.gene.2026.150290

Original

Original request for help

Save

Abstract

En 中文

• Developed a novel prognostic model based on phospholipid metabolism-related genes for osteosarcoma. • Identified a seven-gene signature (GM2A, PIP5K1C, VAC14, PLEKHA8, UBE2L3, RSPO3, CEBPA) with high predictive accuracy. • The risk model effectively stratifies patients into distinct prognostic subgroups with differential immune infiltration. • VAC14 is a potential therapeutic target, with Vorinostat shown to upregulate its expression and induce apoptosis. • Revealed a link between phospholipid metabolism and the TME, suggesting a metabolic-immune axis in OS.

Development of a gene signature related to phospholipid metabolism for prognosis and therapeutic Prediction in Osteosarcoma: Focus on VAC14

Abstract

Journal

Organization