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Development of a new 18F-labeled PET tracer for potential application to HDAC2 neuroimaging

delete2026-03-03
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PRE
AI
Y
Yafei Huang
Y
Yongle Wang
Y
Yanli Wang
程华 cover
程华 (Hua Cheng)
A
Anne Siewko
B
Breanna Lizeth Varela
C
Changning Wang
Y
Yulong Xu *
DOI：10.1016/j.nucmedbio.2026.109620delete
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Abstract

Abstract

En 中文
• HDAC2 inhibitor HYF005 labeled with Fluorine-18 was synthesized and preliminary assessment. • [18F]HYF005 demonstrated appropriate blood-brain barrier (BBB) penetration in rodent models. • [18F]HYF005 holds significant promise as a potential PET imaging probe for the study of the brain's HDAC2 system.
Keywords:
HDAC2
PET imaging
Fluorine-18
blood-brain barrier
radiotracer

Journal

Nuclear Medicine and Biology cover
Nuclear Medicine and Biology
IF:
3
Papers:
3.7K
Citations:
3.2K

Organization

H
Harvard University
Scholars:
26.2W
Papers: 21.9W
Citations: 28.7W
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