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Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs
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DOI：10.1002/bcp.70676.png)
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Abstract
En 中文
Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH treatments (sildenafil, tadalafil, bosentan and ambrisentan).
Keywords:
paediatric
plasma concentration
population pharmacokinetic
pulmonary arterial hypertension
Journal
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3
Papers:
8.5K
Citations:
1.8W
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