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Development of AI-assisted 3D-printed degradable hydrogel microneedles for transdermal delivery of progesterone-loaded solid lipid nanoparticles: a novel approach to slowing Alzheimer’s disease progression
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DOI：10.1016/j.ijpharm.2026.126967.png)
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Abstract
En 中文
• PG-SLNs-loaded 3D-printed MNs were fabricated from LCD 3D printing aided by YOLOv8 object detection. • The prediction model demonstrated high accuracy in selecting biodegradable polymeric resins. • PG-SLNs have been highlighted for their potential to enhance drug solubility and facilitate drug delivery for Alzheimer’s disease. • PG-SLNs-loaded 3D-printed MNs maintained sufficient mechanical strength, enabled efficient transdermal delivery, and exhibited cryoprotection to neuronal cells. • PG-SLNs-loaded 3D-printed MNs represented a novel transdermal drug delivery system, demonstrating practical feasibility for medical applications.
Keywords:
3D-printed microneedles
progesterone-loaded solid lipid nanoparticles
Alzheimer’s disease
transdermal drug delivery
AI-assisted fabrication
Journal
IF:
5.2
Papers:
2.2W
Citations:
6.7W
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Cited Papers