Development of an oral Lactobacillus casei-based recombinant vaccine expressing GCRV-II multi-epitope fusion protein and its protective efficacy against grass carp hemorrhagic disease

Xijia Chen

doi:10.1016/j.fsi.2026.111616

Development of an oral Lactobacillus casei-based recombinant vaccine expressing GCRV-II multi-epitope fusion protein and its protective efficacy against grass carp hemorrhagic disease

2026-08-04

0

PRE

AI

X

Xijia Chen

Y

Yujiao Chen

D

Danwen Wang

J

Jiayi Tang

Z

Zixuan Zhang

F

Feng Cai

Z

Zijia Yin

R

Runzhou Chen

H

Huiling Mao

F

Feiyan Tian *

X

Xiaowen Xu *

C

Chengyu Hu

DOI：10.1016/j.fsi.2026.111616

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Abstract

En 中文

• The screened recombinant antigen VP4274−367-VP5105−336-NS38143−338 exhibits high antigenicity. • Oral administration of the recombinant L. casei vaccine efficiently trigger the mucosal, humoral and cellular immune responses of grass carp without inducing excessive inflammatory stress. • Oral administration of the recombinant L. casei vaccine enhances the resistance of grass carp to GCRV-II infection.

Keywords:

Grass carp reovirus (GCRV)

Subunit vaccine

Outer capsid protein

L. casei

Antiviral protection

Development of an oral Lactobacillus casei-based recombinant vaccine expressing GCRV-II multi-epitope fusion protein and its protective efficacy against grass carp hemorrhagic disease

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