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Developmental plasticity of lymphoid progenitors
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DOI：10.1016/S1044532302000726.png)
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Abstract
En 中文
The identification of the common lymphoid progenitors in mouse bone marrow allows us to directly assess the regulatory mechanisms of lymphoid lineage commitment. The unexpected finding of a latent myeloid differentiation potential in lymphoid progenitors sheds light on the importance of cytokine receptor expression at this stage. We will discuss the biological nature of common lymphoid progenitors as a model of differentiation from multipotent to lineage committed progenitors. Elucidation of this hidden differentiation potential in progenitors will help further our understanding of the molecular mechanisms that control the cell fate determination of not only common lymphoid progenitors, but also their ancestors, hematopoietic stem cells and their descendents such as committed T and B cell progenitors.
Keywords:
hematopoiesis
lineage commitment
cytokine receptor
transdifferentiation
gene expression profile
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