Developmentally defined subcircuits in the hippocampus support spatial learning

doi:10.1016/j.neuron.2026.07.023

Developmentally defined subcircuits in the hippocampus support spatial learning

2026-08-12

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DOI：10.1016/j.neuron.2026.07.023

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• Pyramidal CA3 and CA1 neurons born on the same embryonic birthdate fire together • Associating rewards with new places reorganized coactivity near reward locations • Same-birthdate CA1, but not CA3, neurons coordinated to encode rewards • Learning engaged connectivity from same-birthdate neurons onto CA1 parvalbumin cells

Developmentally defined subcircuits in the hippocampus support spatial learning

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