Dexmedetomidine pre-injection attenuates fear response via prelimbic cortex modulation in an electric shock–induced PTSD adolescent rat model

2026-03-11

PRE

Minhyo Seo

Minji Jang

Sung-Hoon Kim

Yong-Seok Park *

Jihyun Noh *

DOI：10.1016/j.pbb.2026.174187

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• Post-injection of dexmedetomidine did not alter fear-related behavior. • Pre-injection of dexmedetomidine reduced fear-related behavior dose-dependently. • Pre-injection of dexmedetomidine selectively increased c-Fos activity in the mPFC PL.

Keywords:

dexmedetomidine

fear response

prelimbic cortex

PTSD

adolescent rat model

Dexmedetomidine pre-injection attenuates fear response via prelimbic cortex modulation in an electric shock–induced PTSD adolescent rat model

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