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Dextromethorphan induces sub-chronic nephrotoxicity via modulating renin-angiotensin system, renal xenobiotic transport and drug clearance pathway
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DOI：10.1016/j.tice.2026.103563.png)
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Abstract
En 中文
• Sub-chronic DEX exposure induces dose-dependent nephrotoxicity in rats. • DEX intoxication alters renal RAS and xenobiotic handling pathways. • DEX exposure promotes renal oxidative stress and inflammation. • Renal functions were compromised after DEX administration. • DEX exposure disrupts normal structure of renal tissues.
Keywords:
dextromethorphan
nephrotoxicity
renin-angiotensin system
renal xenobiotic transport
oxidative stress
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