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Diabetes mellitus in multiple myeloma and related plasma cell disorders: a review of risk, prognosis, and outcomes
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DOI：10.1038/s41408-026-01504-z.png)
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Abstract
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There is a clear link between type 2 diabetes mellitus (DM) and overall cancer risk. However, studies evaluating type 2 DM and multiple myeloma (MM) risk are limited, and the association is less clear. Understanding the impact of longstanding type 2 DM on organ systems and symptomatology in patients with a subsequent MM diagnosis, alongside potential overlapping toxicities from MM treatment, is crucial. This review summarizes the role of type 2 DM on MM risk and outcomes and explores the various mechanisms underlying these associations. A better understanding of this association will help improve outcomes in diabetic MM patients through lifestyle and drug related interventions. Clinical trial registration: Not applicable.
Keywords:
type 2 diabetes mellitus
multiple myeloma
cancer risk
plasma cell disorders
prognosis
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