Dietary capsaicin attenuates aortic dissection by inhibiting M1 macrophage polarisation and modulating the gut microbiota

Wanqi Lan

doi:10.1016/j.phymed.2026.158269

Dietary capsaicin attenuates aortic dissection by inhibiting M1 macrophage polarisation and modulating the gut microbiota

2026-05-03

0

PRE

AI

W

Wanqi Lan

H

Heng Yang

W

Wu Liu

C

Congcong Li

C

Chao Luo

Y

Yonggang Shi

J

Juesheng Yang

H

Haiyan Xiang

Y

Yongqin Li

Y

Yuqi Yi

J

Jing Wei

Y

Yanhua Tang *

陈廷涛 (Tingtao Chen) *

DOI：10.1016/j.phymed.2026.158269

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Abstract

En 中文

• AD patients showed reduced spicy food intake, lower serum capsaicin, and gut microbiota dysbiosis. • Capsaicin alleviates AD in mice by suppressing M1 polarization, an effect accompanied by the restoration of gut microbiota homeostasis. • Capsaicin inhibits M1 macrophage polarization by modulating the TRPV1/TLR4/MyD88/NF-κB signaling pathway.

Keywords:

capsaicin

Alzheimer's disease

gut microbiota

M1 macrophage polarization

TRPV1/TLR4/MyD88/NF-κB signaling pathway

Dietary capsaicin attenuates aortic dissection by inhibiting M1 macrophage polarisation and modulating the gut microbiota

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