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Dietary exopolysaccharides alleviate SARA–induced colonic dysfunction in Hu sheep by modulating microbiota and enhancing barrier integrity
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DOI：10.1016/j.jnutbio.2026.110461.png)
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Abstract
En 中文
• L. plantarum EPS mitigates SARA-induced colonic dysfunction in Hu sheep. • Dietary EPS restructures colonic microbiota and enriches SCFA-producing taxa. • EPS supplementation restores colonic epithelial barrier and tight junctions. • EPS attenuates inflammation by epigenetically repressing pro-inflammatory genes.
Keywords:
Exopolysaccharides
Subacute ruminal acidosis
Intestinal microbiota
Intestinal immune regulation
Intestinal barrier
ChIP
,
chromatin immunoprecipitation
CRP
,
C-reactive protein
DEGs
,
differentially expressed genes
DSS
,
dextran sulfate sodium
ECM
,
extracellular matrix
EDTA
,
ethylenediaminetetraacetic acid
EPS
,
exopolysaccharides
FDR
,
false discovery rate
FPKM
,
fragments per kilobase of transcript per million mapped reads
HATs
,
histone acetyltransferases
HCD
,
high-concentrate diet
HDAC
,
histone deacetylase
HEPS
,
high-concentrate diet supplemented with 0.2% EPS
H&E
,
hematoxylin and eosin
IFN-γ
,
interferon-gamma
IGF-1
,
insulin-like growth factor 1
IL
,
interleukin
KEGG
,
Kyoto Encyclopedia of Genes and Genomes
LAB
,
lactic acid bacteria
LCD
,
low-concentrate diet
LEfSe
,
linear discriminant analysis effect size
LEPS
,
high-concentrate diet supplemented with 0.1% EPS
LPS
,
lipopolysaccharide
MAPK
,
mitogen-activated protein kinase
MDA
,
malondialdehyde
MHC
,
major histocompatibility complex
NF-κB
,
nuclear factor kappa B
NLRP3
,
NLR family pyrin domain containing 3
SAA
,
serum amyloid A
SARA
,
subacute ruminal acidosis
SCFA
,
short-chain fatty acid
STAT3
,
signal transducer and activator of transcription 3
T-AOC
,
total antioxidant capacity
TJ
,
tight junction
TLR4
,
toll-like receptor 4
TNF-α
,
tumor necrosis factor-alpha
VFA
,
volatile fatty acid
ZO-1
,
zonula occludens-1
Journal
IF:
4.9
Papers:
4.5K
Citations:
1.4W
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