Dietary lutein mitigates high fat diet and lipopolysaccharide induced intestinal barrier dysfunction and immune inflammatory responses in juvenile black seabream (Acanthopagrus schlegelii)

Yangguang Bao

doi:10.1016/j.fsi.2026.111609

Dietary lutein mitigates high fat diet and lipopolysaccharide induced intestinal barrier dysfunction and immune inflammatory responses in juvenile black seabream (Acanthopagrus schlegelii)

2026-07-27

0

PRE

AI

Y

Yangguang Bao

J

Jiayun Zhu

Q

Qiuting Yang

L

Liwen Wu

W

Wenli Zhao

T

Tingting Zhu

P

Peng Sun

Q

Qicun Zhou

M

Min Jin *

DOI：10.1016/j.fsi.2026.111609

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Abstract

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• Dietary lutein mitigated high-fat diet-induced immune dysfunction. • LU restored intestinal barrier function in HFD-fed black seabream. • LU reduced LPS-triggered inflammation and apoptosis-related responses. • LU suppressed LPS-induced complement activation and tlr/myd88/nf-κb signaling.

Keywords:

Acanthopagrus schlegelii

Lutein

High-fat diet

Inflammatory response

Intestinal barrier

Lipopolysaccharide challenge

Dietary lutein mitigates high fat diet and lipopolysaccharide induced intestinal barrier dysfunction and immune inflammatory responses in juvenile black seabream (Acanthopagrus schlegelii)

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