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Dietary Protein Source Mediates Colitis Pathogenesis Through Bacterial Modulation of Bile Acids
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DOI：10.1016/j.jcmgh.2026.101825.png)
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Abstract
En 中文
Evidence-based dietary recommendations for individuals with inflammatory bowel diseases are limited. Red meat consumption is associated with increased inflammatory bowel disease incidence and relapse in patients, suggesting that switching to a plant-based diet may limit gut inflammation. However, the components and mechanisms underlying the differential effects of these diets remain poorly understood. This study investigated the differential impact of dietary protein source on experimental colitis and related mechanisms.
Keywords:
Dextran Sodium Sulfate
Experimental Colitis
Interleukin10 Deficient Mice
Microbiome
16S-seq
16S sequencing
AM
A muciniphila ATCC BAA-835
BA
bile acid
BP
beef protein
BP-psyllium
BP diet in which cellulose fiber was replaced with psyllium
CBA
conjugated bile acid
DAI
Disease Activity Index
DSS
dextran sodium sulfate
EER
Escherichia coli, Enterococcus faecalis, and Ruminococcus gnavus
FISH
fluorescence in situ hybridization
FMT
fecal microbiota transplantation
GF
germ-free
H&E
hematoxylin and eosin
IBD
inflammatory bowel diseases
LYH-BHI medium
brain-heart infusion medium supplemented with 5 g/L yeast extract, 0.5 g/L L-cysteine, and 5 mg/L hemin
MA
mouse-adapted
MALDI
matrix-assisted laser desorption/ionization
MS
mass spectroscopy
PBS
phosphate-buffered saline
PCoA
Principal Coordinates Analysis
PCoA1
Principal Coordinate Axis 1
PCoA2
Principal Coordinate Axis 2
PP
pea protein
qRT-PCR
quantitative real-time polymerase chain reaction
rRNA
ribosomal RNA
SPF
specific pathogen–free
TCA
taurocholic acid
WT
wild-type
Journal
IF:
7.4
Papers:
1.5K
Citations:
6.8K
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Cited Papers