1
Return

Dietary tryptophan supplementation prevents sepsis by enhancing macrophage bacterial defense through GPR37 activation

delete2026-06-08
delete0
delete
OA
AI
X
Xie, Shihao
L
Lyu, Fengyuan
G
Gao, Kai
C
Chen, Qi
C
Chen, Meiling
Y
Yan, Xiaofei
L
Li, Ting
L
Li, Hongbin
Z
Zhao, Yuechu
Q
Qu, Lingying
C
Chen, Peng
L
Li, Xin
Z
Zhang, Yuelin
H
Hu, Bei
DOI：10.1097/CM9.0000000000004108delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Sepsis, a critical and life-threatening condition, is one of the most common causes of death among inpatients. Emerging evidence suggests that active metabolites derived from gut microbe-associated metabolism of dietary essential amino acid L-tryptophan (Trp) help the host in combating infectious diseases. This study aims to investigate the mechanisms through which these active metabolites regulate sepsis progression.
Keywords:
Dietary tryptophan
Sepsis
Gut microbiota
Indole-3-pyruvate
Macrophage
Phagocytosis
GPR37
GTPases

Journal

Chinese Medical Journal cover
Chinese Medical Journal
IF:
7.3
Papers:
1.2W
Citations:
1.5W

Organization

S
southern medical university
Scholars:
1.1W
Papers: 2.9K
Citations: 5
S
south china university of technology
Scholars:
6.5W
Papers: 5.0W
Citations: 85
Cited Papers

Cited Papers

Citing Papers

Citing Papers