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Dietary vitamin A restricts intestinal tuft cell differentiation
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DOI：10.1016/j.celrep.2026.117802.png)
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Abstract
En 中文
• Dietary vitamin A and retinoic acid limit tuft cell numbers in the intestine • Epithelial-intrinsic retinoic acid receptor directs tuft cell differentiation • Vitamin A deficiency enhances anti-helminth type 2 immunity through tuft cells • Tuft cell regulation by Vitamin A is mediated by Sprouty2 in intestinal stem cells
Keywords:
Diet
Vitamin A
Tuft cell
Retinoic acid
Intestine
Stem cell
Epithelial
ILC
Differentiation
CP: metabolism
CP: stem cell research
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