Diethylene glycol dibenzoate an emerging plasticizer disrupts bone formation via MMP3 targeting: Insights from bioinformatics and in vitro validation

2026-08-05

Miao Li

Genning Mai

Chenhui Meng

Xiaoxuan Li

Ruijun Zhao

Zheya Feng

Zhaofeng Pan

Fanchen Wang

Jiajun Ling

Haibin Wang *

贺

贺琪 (Qi He) *

DOI：10.1016/j.ecoenv.2026.120597

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• DEGDB inhibits osteogenic differentiation of bone marrow mesenchymal stem cells at non-cytotoxic concentrations. • Bioinformatics and machine learning identify MMP3 as a key target of DEGDB in osteoporosis. • DEGDB activates NF-κB signaling and upregulates MMP3 at both transcriptional and protein levels. • Molecular docking and dynamics confirm stable DEGDB-MMP3 binding with high affinity. • First evidence linking DEGDB exposure to bone disruption via the NF-κB/MMP3 axis.

Keywords:

Diethylene glycol dibenzoate

Bone formation

MMP3

Machine learning

Vitro validation

Diethylene glycol dibenzoate an emerging plasticizer disrupts bone formation via MMP3 targeting: Insights from bioinformatics and in vitro validation

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