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Differentiable model-based adaptive optics for two-photon microscopy
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DOI：10.1364/OE.424344.png)
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Abstract
En 中文
Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be combined with the optimization techniques of machine learning frameworks to find aberration corrections, as was demonstrated for focusing a laser beam through aberrations onto a camera [Opt. Express 28 26436 (26436)]. Here, we extend this approach to two-photon scanning microscopy. The developed sensorless technique finds corrections for aberrations in scattering samples and will be useful for a range of imaging application, for example in brain tissue. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Keywords:
WAVE-FRONT-SENSOR
PHASE RETRIEVAL
Journal
IF:
3.3
Papers:
6.1W
Citations:
14.3W