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Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis: A randomised placebo-controlled MRI study

delete2026-07-24
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OA
AI
S
Sidhant Chopra *
A
Alexander Holmes
A
Ashlea Segal
X
Xi-Han Zhang
S
Shona M. Francey
B
Brian O’Donoghue
V
Vanessa Cropley
B
Barnaby Nelson
J
Jessica Graham
L
Lara Baldwin
H
Hok Pan Yuen
A
Andrew Thompson
K
Kelly Allott
M
Mario Álvarez‐Jiménez
S
Susy Harrigan
A
Avram J. Holmes
C
Christos Pantelis
S
Stephen J. Wood
P
Patrick McGorry
A
Alex Fornito
DOI:10.1016/j.biopsych.2026.06.028delete
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Abstract

Abstract

En 中文
Cortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of psychosis and can progress with ongoing illness. A major unresolved question concerns whether these changes are driven by the illness or represent iatrogenic effects of antipsychotics.

Journal

Biological Psychiatry cover
Biological Psychiatry
IF:
9
Papers:
1.5W
Citations:
4.0W

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St Vincent's University Hospital
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rutgers university
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yale university
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The University of Melbourne
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monash university
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university of melbourne
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