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Differential examination of the diagnostics and symptom presentation of early- versus late-onset primary progressive aphasia (PPA)
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DOI：10.1080/02687038.2026.2651425.png)
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Abstract
En 中文
BackgroundPrimary progressive aphasia (PPA) is a neurodegenerative condition characterized by insidious onset of gradually progressive language dysfunction as the initial problem. The typical age of onset is generally within the 5th or 6th decade but there is limited research exploring onset outside of these decades of life.AimsThe current study explored clinical characteristics and cognitive and psychiatric test performance among patients diagnosed with PPA in an outpatient neuropsychology clinic to determine how age of onset may correspond with diagnostic characteristics, symptom profiles, and service utilization.Methods & ProceduresMethods involved a retrospective analysis of neuropsychological test data of 69 individuals diagnosed with PPA through an outpatient neuropsychology clinic, 33 of whom had symptom onset prior to age 70 and 36 with onset on or after age 70.Outcomes & ResultsResults found an earlier age of onset for semantic variant PPA compared to other variants and differences in specific language test performance between individuals across PPA subtypes and age groups.ConclusionAlthough this study was limited by small sample size and heterogenous test batteries, results were in alignment with the limited literature and suggest that differences may exist in clinical presentation between early- and late-onset patients with PPA.
Keywords:
Primary progressive aphasia
aphasia
dementia
language
aging
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