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Differential mirroring between in vivo insulin secretion and ex vivo islet function in individuals with and without diabetes
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DOI：10.1016/j.metabol.2026.156715.png)
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Abstract
En 中文
• Ex vivo glucose-stimulated insulin secretion shows marked inter-donor heterogeneity in isolated human islets. • A direct correspondence between ex vivo islet function and in vivo β cell function emerges selectively in T2D. • Ex vivo insulin secretion is positively associated with glucose-driven β cell function and inversely associated with potentiation in T2D. • In T2D, impairment of network-dependent regulation may unmask intrinsic islet defects and enable direct in vivo – ex vivo functional mirroring.
Keywords:
Islets of Langerhans
β cells
Insulin secretion
Type 2 diabetes
Islets stimulation
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