Differential response of human plasmacytoid pre-dendritic cells to SARS-CoV-2 variants

2025-08-18

Daria Kartasheva-Ebertz

Dimitri Topalis

Claudia Umaña-Diaz

Okan Ayas

Laurine Couture

Pierre Tonnerre

Jasna Medvedovic

Laurent Meertens

Vassili Soumelis *

Ali Amara *

DOI：10.1016/j.isci.2025.113394

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Abstract

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• Plasmacytoid cells (pDCs) mount distinct immune responses to SARS-CoV-2 variants • Omicron BA.1 induces P3-pDCs with reduced type I/III interferon transcripts • P3-pDCs secrete more pro-inflammatory cytokines than P1-pDCs • CD4+ T cell priming is stronger with Omicron BA.1 than Alpha or Delta variants

Keywords:

pDCs

SARS-CoV-2 variants

type I/III interferon

pro-inflammatory cytokines

CD4+ T cell priming

Differential response of human plasmacytoid pre-dendritic cells to SARS-CoV-2 variants

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