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DILI-Context: A Dose- and Exposure-Enriched Knowledge Base for Translational Liver Safety Assessment

delete2026-06-27
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PRE
AI
R
Rohola Zandie
R
Robert Betancort
F
Farhan Khodaee *
DOI：10.1093/toxsci/kfag077delete
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Abstract

Abstract

En 中文
Drug-induced liver injury (DILI) is a major cause of drug development failure and post-marketing withdrawal. While assessing clinical hepatotoxic risk is critical for decision-making, most benchmark datasets represent DILI with categorical hazard labels rather than exposure-dependent risk measures. As a result, the current understanding of DILI risk focuses on hazard rather than context-dependent exposure risk.

Journal

Toxicological Sciences cover
Toxicological Sciences
IF:
4.1
Papers:
7.2K
Citations:
1.6W

Organization

A
absentia labs, inc
Scholars:
4
Papers: 1
Citations: 0
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