.png){kind=icon}
.png){kind=icon}
Return
Diosmin and its aglycone form Diosmetin as potential therapeutics for cardiovascular diseases
.png){kind=icon}
OA
AI
S
P
S
V
V
DOI：10.1016/j.jff.2026.107383.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Cardiovascular disease continues to be the leading cause of death worldwide. • Diosmin improved vascular function by reducing VCAM-1, ICAM-1, as well as p-JNK and p-NF-κB proteins. • Diosmin and diosmetin exerted antioxidant and anti-apoptotic effects by increasing the ratios of phospho-AKT to AKT and phospho-Nrf2 to Nrf2. • Diosmetin has the capacity to reduce autophagy through the inhibition of the PI3K/Akt signaling pathway and endothelial-mesenchymal transformation via the Src-targeting pathway. • The collected findings emphasize the role of diosmin and diosmetin in safeguarding against heart failure, atherosclerosis, hyperlipidemia, and vascular dysfunction. • This addition provides a novel therapeutic and preventive choice for cardiovascular disease.
Keywords:
Diosmin
Diosmetin
Cardiovascular disease
Heart
Inflammation
2-DE
Two-dimensional gel electrophoresis
5-HMF
5-hydroxymethylfurfural
AA
Arachidonic Acid
AB
Aortic banding
ACE
Angiotensin-converting enzyme
Ach
Acetylcholine
AG
Anion gap
Ages
Advanced glycation end products
AKT
Protein kinase B
ALP
Alkaline phosphatase
ALT
Alanine aminotransferase
AMPK
Adenosine 5′-monophosphate-activated protein kinase
ANP
Atrial natriuretic peptide
AP-1
Activator protein-1
ASLS
Analogue scale line score
AST
Aspartate aminotransferase
ATF6
Activating transcription factor 6
ATP
Adenosine triphosphate
AVP
Ambulatory venous pressure
AVS
Average venous symptom score
Bcl-2/Bax
B-cell lymphoma protein 2 /associated X
BCRP
breast cancer resistance protein
BMI
Body mass index
BNP
Brain natriuretic peptide
BP
blood pressure
CAT
Catalase
CED
Coefficient of endothelial damage
CEP350
Centrosome-associated protein 350
CFV
Common femoral veins
CIVIQ
Chronic venous insufficiency questionnaire
CK
Creatine kinase
CK-MB
Creatine kinase-myocardial band
CMECs
Cardiac microvascular endothelial cells
CoCl2
Cobalt chloride
COX-2
Cyclooxygenase-2
CPK
Creatinine phosphokinase
CRP
C-reactive protein
cTnI
Cardiac Troponin I
cTnT
Cardiac Troponin T
CVD
Cardiovascular Disease
CVI
Chronic Venous Insufficiency
DALYs
Disability-adjusted life years
DCM
Diabetic cardiomyopathy
DIOS
Diosmetin
Diosmetin-7- O-glucoside
Diosmetin-7-O-β-D-glucopyranoside
DMSO
Dimethyl sulfoxide
DOCA
Deoxycorticosterone acetate
Dox
Doxorubicin
DP
Diastolic pressure
DPPH
1,1-diphenyl-2-picrylhydrazyl
DRESS
drug reaction with eosinophilia and systemic symptoms
DUS
Sequential duplex ultrasound
DVT
Deep vein thrombosis
ECG
Electrocardiography
ECS
Elastic compression stockings
ED
Endothelial dysfunction
EFS
Electrical field stimulation
EndMT
Endothelial-mesenchymal transformation
ER
Endoplasmic reticulum
FGF
Fibroblast growth factors
FRAP
Ferric Reducing Antioxidant Power
FS
Fraction shortening
GGT
Gamma-glutamyl transpeptidase
GPx
Glutathione peroxidase
GR
Glutathione reductase
GSH
Glutathione
GST
Glutathione S-transferase
GSV
Greater saphenous vein
HBMVEC
Human brain microvascular endothelial cells
HDC
Hesperidin/diosmin compound
HDL-C
High-density lipoprotein cholesterol
HFD
High-fat diet
HFHS
High-fat high-sucrose
HIF
Hypoxia-inducible factor
HMG-CoA
3-hydroxy-3-methyl glutaryl CoA
HO-1
Heme oxygenase-1
HR
Heart rate
HUVECs
Human umbilical vein endothelial cells
HVI
Chronic venous insufficiency
HVVEC
Human varicose vein endothelial cells
I/R
Ischemia-reperfusion
ICAM-1
Intracellular adhesion molecule-1
ICDH
Isocitrate dehydrogenase
IHD
Ischemic heart disease
IL
Interleukin
INR
International normalized ratio
IRE1α
Inositol-requiring enzyme type 1α
ISO
Isoproterenol
IVC
Inferior vena cava
IVCS
Iliac vein compression syndrome
IVS
Iliac vein stenosis
Keap1
Klech-like ECH-associated protein1
LDH
Lactate dehydrogenase
LDL-C
Low-density lipoprotein cholesterol
L-NAME
N-nitro-L-arginine methyl ester
LPS
Lipopolysaccharides
LV
Left ventricular
LVEF
Left ventricular ejection fraction
LVH
Left ventricular hypertrophy
LVWT
Left ventricular wall thickness
MAP
Mean arterial pressure
MCP-1
Monocyte chemoattractant protein-1
MDA
Malondialdehyde
MDH
Malate dehydrogenase
MI
Myocardial ischemia
MMP-9
Matrix metalloproteinase 9
MPFF
Micronized purified flavonoid fraction
mRNA
Messenger Ribonucleic acid
MS
Metabolic syndrome
MTX
Methotrexate
NE
Norepinephrine
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells
NO
Nitric oxide
NOS
Nitric oxide synthase
NQO1
NAD(P)H quinone oxidoreductase1
NRCM
Neonatal rat ventricular cardiomyocytes
Nrf2
Nuclear factor erythroid 2-related factor
OATPs
organic anion transporting polypeptides
Pae
Paeonol
p-AMPK
Phosphorylated adenosine 5′-monophosphate-activated protein kinase
PE
Phenylephrine
PERK
Protein Kinase R-like ER Kinase
PGE2
Prostaglandin E2
PI3K
Phosphatidylinositol 3-kinase
p-JNK
Phospho-c-Jun N-terminal kinases
PKCα
Protein kinase C α
PLA2
Phospholipase A2
PLG
Plasminogen
PMA
Phorbol 12-myristate 13-acetate
PP
Pulse rate
PTS
Post-Thrombotic Syndrome
p-ULK1
Phosphorylated unc-51-like autophagy activating kinase 1
PV
Popliteal veins
QPCR
Quantitative Polymerase Chain Reaction
RAS
Rate of ankle swelling
RF
Skin flux at rest
ROS
Reactive oxygen species
RTC
Randomized controlled trial
SDH
Succinate dehydrogenase
SFV
Superficial femoral veins
SOD
Superoxide dismutase
SP
Systolic pressure
STZ
Streptozotocin
TBARS
Thiobarbituric acid reactive substances
TCA
Tricarboxylic acid
TG
Triglycerides
TGF-β
Transforming growth factor β
TLR4
Toll-Like Receptor 4
TNF-α
Tumor necrosis factor alpha
TP
Trichosanthis pericarpium
VAS
Visual analogue scale
VCAM-1
Vascular cell adhesion molecule-1
VEGF
Vascular endothelial growth factor
VLDL-C
Very low-density lipoprotein cholesterol
VRV-PL-5
Vipera russelli venom phospholipase A2 fraction V
VRV-PL-8a
Vipera russelli venom phospholipase A2 fraction VIIIa
α-KDH
alpha-ketoglutarate dehydrogenase
α-SMA
α-Smooth muscle actin
Journal
IF:
4
Papers:
7.1K
Citations:
2.6W
Organization
Cited Papers