Dipolar extracellular potentials generated by axonal projections

doi:10.75554/elife.26106

Dipolar extracellular potentials generated by axonal projections

2017-09-05

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Carr, Catherine Emily

DOI：10.75554/elife.26106

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Extracellular field potentials (EFPs) are an important source of information in neuroscience, but their physiological basis is in many cases still a matter of debate. Axonal sources are typically discounted in modeling and data analysis because their contributions are assumed to be negligible. Here, we established experimentally and theoretically that contributions of axons to EFPs can be significant. Modeling action potentials propagating along axons, we showed that EFPs were prominent in the presence of terminal zones where axons branch and terminate in close succession, as found in many brain regions. Our models predicted a dipolar far field and a polarity reversal at the center of the terminal zone. We confirmed these predictions using EFPs from the barn owl auditory brainstem where we recorded in nucleus laminaris using a multielectrode array. These results demonstrate that axonal terminal zones can produce EFPs with considerable amplitude and spatial reach.

Keywords:

LOCAL-FIELD POTENTIALS

CURRENT SOURCE-DENSITY

AUDITORY BRAIN-STEM

OWL TYTO-ALBA

COCHLEAR NUCLEUS MAGNOCELLULARIS

COINCIDENCE DETECTOR NEURONS

INTERAURAL TIME DIFFERENCES

BARN OWL

EVOKED-POTENTIALS

SPIKING ACTIVITY

Dipolar extracellular potentials generated by axonal projections

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