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Discovery of antimicrobial peptides from incomplete biosynthetic gene clusters to combat multidrug-resistant bacteria
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OA
AI
Y
X
J
Y
J
Z
张
朱
陈
J
Q
Q
DOI：10.1016/j.xcrm.2026.102982.png)
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Abstract
En 中文
• An evolution-guided algorithm broadly identifies NRPs from incomplete BGCs • Paenibacillus genomes yield five polymyxin-class antimicrobial peptides (NP001–005) • NP001 is active against Gram-negative bacteria (MCR-1) in mice • NP001 binds to bacterial membranes and lyses cells; residue 10 plays a key role
Keywords:
antimicrobial peptide
antibiotic discovery
polymyxin
nonribosomal peptides
multidrug-resistant bacteria
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10.6
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2.2K
Citations:
8.9K
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