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Discovery of Insect Antifeeding Limonoids from Trichilia connaroides
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DOI：10.1021/acs.jnatprod.6c00339.png)
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Abstract
En 中文
Exploration of the Trichilia connaroides led to the isolation of 16 previously undescribed limonoids (1–16). Compounds 1 and 2 were characterized by polycyclic caged seco-phragmalin frameworks, while 8 possessed a trans-fused B/C ring system. An insect antifeedant bioassay against Spodoptera exigua demonstrated that compounds 2, 11, 12, and 16, at a concentration of 0.005 mg/cm2, exhibited potent antifeedant effects comparable to that of azadirachtin and showed no appreciable cytotoxicity toward murine AML12 hepatocytes.
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