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Disruption of microhomology-mediated end joining in Ewing sarcoma

delete2026-07-21
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OA
AI
S
Shuhei Asada *
G
Guangli Zhu
J
Jithma P. Abeykoon
Y
Yutaro Tanaka
H
Huy Tien Nguyen
Y
Yuna Hirohashi
D
Divya Iyer
N
Nicholas W. Ashton
S
Sirisha Mukkavalli
M
Martha Velazquez
L
Lige Jiang
M
Miles Del Busso
J
Judith Jebastin Thangaiah
S
Steven I. Robinson
K
Kalindi Parmar
E
Eliezer M. Van Allen
R
Riaz Gillani
G
Geoffrey I. Shapiro
A
Alan D. D’Andrea *
DOI：10.1016/j.molcel.2026.06.038delete
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Abstract

Abstract

En 中文
• Ewing sarcoma is characterized by reduced Polθ expression and impaired MMEJ activity • The EWSR1/FUBP1/KHSRP complex prevents POLQ exon 25 skipping • The EWS-FLI1 oncoprotein disrupts EWSR1-dependent POLQ splicing • MMEJ deficiency makes Ewing sarcoma highly dependent on other DNA repair pathways
Keywords:
Ewing sarcoma
DNA double-strand breaks
alternative end joining
TMEJ
DNA-PKc
CDK12
RBM39
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Journal

Molecular Cell cover
Molecular Cell
IF:
16.6
Papers:
1.0W
Citations:
8.5W

Organization

H
harvard medical school
Scholars:
4.6K
Papers: 2.1K
Citations: 2
M
mayo clinic
Scholars:
8.0W
Papers: 6.5W
Citations: 84
B
Broad Institute of MIT and Harvard
Scholars:
1.2K
Papers: 317
Citations: 0
D
dana-farber cancer institute
Scholars:
1.1K
Papers: 331
Citations: 0
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