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Distinct neural substrates of affective distress and communicative disability in head and neck cancer: A cross-sectional 18F-FDG PET study
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DOI：10.1016/j.jpsychores.2026.112914.png)
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Abstract
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• Depression and voice handicap show dissociable metabolic correlates in HNC. • Depression was linked to lower Broca and higher left insula metabolism. • Voice handicap showed exploratory links with lower hippocampal metabolism. • Depression was site-independent, whereas voice handicap was site-dependent. • Routine oncological PET may inform psychosomatic research hypotheses.
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