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Distribution of Some Antibiotic Resistance Genes Among Carbapenem-Resistant Acinetobacter Baumannii Isolated From Patients Lying ICU in AL-Najaf /Iraq
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DOI：10.21123/2411-7986.5231.png)
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Abstract
En 中文
Acinetobacter baumannii is a significant nosocomial pathogen, affecting immunocompromised and critically ill patients in intensive care units (ICUs). The emergence of carbapenem-resistant A. baumannii (CRAB) poses a threat due to its resistance to multiple antibiotics. This study investigates the prevalence of carbapenemase-encoding genes among CRAB isolates from ICU patients at AL-Sadder hospital/ Najaf. Eight sputum specimens were collected from ICU patients suspected of A. baumannii. The isolates were identified through morphological, biochemical tests and the Vitek 2 Compact system. Antibiotic sensitivity was determined by the Vitek 2 Compact system (using AST card). only 5 A. baumannii isolates have been identified and all isolates were resistant to most antibiotics and these isolates were detected as CRAB. minocycline and doxycycline showed the lowest resistance, while no resistance to colistin. Phenotypically, all isolates were MBL producers, while none of the isolates had the ability to produce carbapenemase. PCR results showed the prevalence of bla(OXA51-like) (100%), followed by bla(OXA24-like) (80%) and bla(NDM) (40%) while bla(GES) was detected in 20% of isolates. All CRAB isolates were lacking bla(KPC). Sixty percent of MBL producer CRAB were possessed both bla(OXA51like) and bla(OXA24-like), while 20% of MBL producer CRAB possessed bla(OXA51-like), bla\textsubscriptGES, bla(NDM), and bla(OXA24-like), whereas other 20% isolates possessed bla(OXA51like) and bla(NDM). The study highlights the high prevalence of carbapenemase genes among CRAB isolated from ICU patients. These findings underscore the need for effective infection control measures and novel treatment strategies to combat multi-drug resistant A. baumannii in ICU settings.
Keywords:
Acinetobacter baumannii
Carbapenemase genes
Carbapenem-resistant
Metallo-beta-lactamase
PCR
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