.png){kind=icon}
.png){kind=icon}
Return
Diterpenoids with potential anti-inflammatory activity from the aerial parts of Nepeta glutinosa
.png){kind=icon}
PRE
AI
M
R
N
A
B
DOI：10.1016/j.phytochem.2026.114887.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
A phytochemical study on the aerial parts of Nepeta glutinosa Benth. from Tajikistan led to the isolation of twelve previously undescribed diterpenoids, designated nepglutinones A-L, along with three known analogues. Their structures were elucidated by comprehensive spectroscopic analysis. The absolute configurations of nepglutinones A and D were unequivocally established by single-crystal X-ray diffraction analysis, while those of the remaining undescribed compounds were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. All isolates were evaluated for their effects on cell viability and inhibition of nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Nepglutinone F reduced cell viability to 53.3% at 100 & micro;M. In the anti-inflammatory assay, nepglutinones B and G, the known compound 14 alpha,18-dihydroxy-7,15-isopimaradiene, and the ethyl acetate fraction showed weak inhibition of NO production, with IC 50 values of 61.5 f 1.59, 69.9 f 1.49, 65.3 f 1.76 & micro;M, and 44.95 f 0.48 & micro;g/mL, respectively (andrographolide IC 50 = 5.49 f 0.14 & micro;M).
Keywords:
Nepeta glutinosa
Lamiaceae
Diterpenoids
Nepglutinones A-L
Structure elucidation
Anti-inflammatory activity
Journal
IF:
3.4
Papers:
1.3W
Citations:
3.2W
Organization
Cited Papers