Substitution of lithogenic with pedogenic soil carbonates in Korean coastal rice paddy under desalinization: Evidences from δ13C

Seo-Woo Park

doi:10.1016/j.agee.2025.109993

DLX2 drives vascular calcification in chronic kidney disease through glycolytic activation: a mechanism epigenetically regulated by HDAC2

2026-06-18

0

PRE

AI

Q

Qun Huang

P

Pai Liu

Z

Zixia Zhao *

G

Guangyu Zhou *

DOI：10.1016/j.intimp.2026.117025

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• HDAC2 epigenetically silences DLX2 by reducing H3K9ac at its promoter. • DLX2 knockdown attenuates VSMC calcification and glycolysis in vitro and in vivo. • The pro-calcific effect of DLX2 is mediated via WNT1/β-catenin-glycolysis axis.

DLX2 drives vascular calcification in chronic kidney disease through glycolytic activation: a mechanism epigenetically regulated by HDAC2

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