.png){kind=icon}
Return
DNA Damage Response
.png){kind=icon}
OA
AI
DOI：10.1101/cshperspect.a000745.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.
Keywords:
NUCLEOTIDE EXCISION-REPAIR
DOUBLE-STRAND BREAKS
RNA-POLYMERASE-II
CHROMATIN REMODELING COMPLEXES
IN-SITU VISUALIZATION
PIGMENTOSUM GROUP-E
GROUP-C PROTEIN
MAMMALIAN-CELLS
HOMOLOGOUS RECOMBINATION
LIVING CELLS
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
10.1
Papers:
3.0K
Citations:
1.3W
Organization
Cited Papers
No cited papers available