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DNA framework–based molecular transformer for logic-driven precision diagnostics
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DOI：10.1126/sciadv.aeb5612.png)
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Abstract
En 中文
Precision diagnostics requires logical integration of diverse biomarker information, but molecular heterogeneity and inconsistent identification kinetics hinder robust logic analysis. To overcome this, we develop a universal molecular transformer using DNA tetrahedral frameworks (DTFs) as programmable scaffolds. This system converts diverse biomarkers including proteins and variable-length nucleic acids into uniform 22-nucleotide DNA sequences, normalizing information dimensionality and identification kinetics. These uniform sequences serve as inputs for three fundamentals Boolean logic gates (AND, OR, and INHIBIT), enabling programmable molecular decision-making. Integrated on a gold-chip platform, the DTF transformer and logic system achieved statistically significant discrimination (P < 0.0001) among patients with prostate cancer, patients with benign prostatic hyperplasia, and healthy individuals using only two biomarkers (prostate-specific antigen and ALU115). By unifying signal transformation for Boolean logic computation, we resolve the critical challenges in molecular heterogeneity and establish a versatile platform for next-generation precision diagnostics.
Keywords:
DNA tetrahedral frameworks
molecular transformer
Boolean logic gates
precision diagnostics
biomarker integration
Journal
IF:
12.5
Papers:
2.0W
Citations:
18.1W