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DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores
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DOI：10.1002/adfm.202523998.png)
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Abstract
En 中文
The increasing demand for high-capacity data storage continues to drive innovation in memory technologies. DNA has recently emerged as a promising medium due to its exceptionally high data density and long-term stability. Here, a DNA-based data storage and readout scheme is presented that leverages sapphire-supported, low-noise solid-state nanopores for reliable detection of nanostructured DNA. Data are encoded onto four-helix bundle (4HB) DNA structures, enabling flexible programmability and secure readout. The sapphire-supported nanopores demonstrate a high signal-to-noise ratio (≈22) under a 250 kHz filtering frequency, allowing precise signal discrimination during readout. Using a decision-tree supervised learning algorithm, up to ≈93% of encoded messages are accurately classified, demonstrating the feasibility of letter and message encoding for information retrieval. This work highlights the potential of integrating DNA nanostructures with low-noise nanopore technology for high-density, secure, and scalable data storage applications.
Keywords:
cryptography
data encryption
DNA origami
DNA storage
helix bundles
low-noise sensing
sapphire-supported nanopores
Journal
IF:
19
Papers:
3.4W
Citations:
32.1W