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DNA methylation analysis uncovers a fine-tuned regulation of expression of the polymeric Ig receptor gene in the Antarctic teleost Trematomus bernacchii
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DOI：10.1016/j.fsi.2025.111078.png)
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Abstract
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• First evidence of epigenetic regulation of immune gene in Antarctic teleosts. • Two CpG islands identified in promoter and intronic regions of pIgR gene. • Promoter CpG island shows tissue-specific methylation. • pIgR expression associates with tissue-specific promoter CpG methylation. • Intronic CpG island is hypermethylated, likely silencing transposon activity.
Keywords:
Cold adaptation
Notothenioidei
Teleost adaptive immunity
Genome evolution
Epigenetic modifications
DNA methylation
Gene locus structure
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