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DNA Sequential Logic Gate Using Two-Ring DNA
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DOI：10.1021/acsami.6b00847.png)
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Abstract
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Sequential DNA detection is a fundamental issue for elucidating the interactive relationships among complex gene systems. Here, a sequential logic DNA gate was achieved by utilizing the two-ring DNA structure, with the ability to recognize before and after triggering sequences of DNA signals. By taking advantage of a loop-open mechanism, separations of two-ring DNAs were controlled. Three triggering pathways with different sequential DNA treatments were distinguished by comparing fluorescent outputs. Programmed nanoparticle arrangement guided by interlocked two-ring DNA was also constructed to demonstrate the achievement of designed nanostrucutres. Such sequential logic DNA operation may guide future molecular sensors to monitor more complex gene network in biological systems.
Keywords:
DNA logic gate
sequential detection
interlocked structure
two-ring DNA
gold nanoparticle
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