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Dnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4
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DOI：10.1002/jcsm.70332.png)
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Abstract
En 中文
Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and metabolism.
Keywords:
Antarctic fish
Dnajb5
HDAC4
mitochondrial biogenesis
mTOR
muscle regeneration
myogenesis
Ppargc1a
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