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Do G4 ligands induce mitochondrial dysfunction without ROS induction
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DOI：10.1016/j.isci.2026.116036.png)
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Abstract
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• Mito-HiCP quantitatively profiles mitochondrial function and redox states • G4 ligands depolarize mitochondria without ROS bursts • MMP-mtROS uncoupling reveals tumor-selective vulnerability • 360 A drives ROS suppression and mitochondrial dysfunction
Keywords:
Biochemistry
molecular biology
cell biology
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