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Driver Mutation Subtypes Differentially Shape Immune Evasion Landscapes in Melanoma: An AI-Driven Inflammatory Pathway Model Implicating CCNE1

delete2026-06-27
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OA
AI
C
Chong Mao
G
Guobin Chen
J
Jiayu Tang
R
Rao Leng
X
Xiyuan Zhou *
J
Jianing Yang *
DOI:10.1155/humu/6776070delete
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Abstract

Abstract

En 中文
Melanoma harbors highly heterogeneous tumor immune microenvironments shaped by driver mutations in BRAF, NRAS, and NF1. How mutational context modulates inflammatory signaling and immune evasion mechanisms of prognosis-related genes remains poorly understood.
Keywords:
CCNE1
machine learning
melanoma
prognostic model
tumor immune microenvironment
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Journal

Human Mutation cover
Human Mutation
IF:
3.7
Papers:
5.1K
Citations:
1.3W

Organization

U
university of electronic science and technology of china
Scholars:
1.1W
Papers: 4.3K
Citations: 4
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