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Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management
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DOI：10.1016/j.jaad.2023.02.073.png)
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Abstract
En 中文
Drug -induced hypersensitivity syndrome, also known as drug reaction with eosinophilia and systemic symptoms, is a severe cutaneous adverse reaction characterized by an exanthem, fever, and hematologic and visceral organ involvement. The differential diagnosis includes other cutaneous adverse reactions, infections, inflammatory and autoimmune diseases, and neoplastic disorders. Three sets of diagnostic criteria have been proposed; however, consensus is lacking. The cornerstone of management is immediate discontinuation of the suspected drug culprit. Systemic corticosteroids remain first -line therapy, but the literature on steroid -sparing agents is expanding. Longitudinal evaluation for sequelae is recommended. Adjunctive tests for risk stratification and drug culprit identification remain under investigation. Part II of this continuing medical education activity begins by exploring the differential diagnosis and diagnosis of druginduced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms and concludes with an evidence -based overview of evaluation and treatment. ( J Am Acad Dermatol 2024;90:911-26.)
Keywords:
delayed hypersensitivity reaction
DHR
DiHS
DRESS
drug rash
drug-induced hypersensitivity syndrome
drug reaction
drug reaction with eosinophilia and systemic symptoms
eosinophilia
exanthem
exanthematous drug eruption
hypersensitivity
maculopapular eruption
morbilliform eruption
severe cutaneous adverse drug reaction
SCAR
Journal
IF:
11.8
Papers:
2.6W
Citations:
3.9W
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